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THE Graft

Clinical proven natural bone substitute

THE GraftTM is a natural, porcine bone mineral matrix for bone reconstruction which likens the physical and chemical aspects of the mineralized matrix of human bone. Over time replaced with newly formed vascularized bone for long term results.1

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THE Graft™ features and inventions

Safe and clean

Safety and purity are an important concern when using a biomaterial. Thanks to the highly efficient patented manufacturing process THE GraftTM is virtually free from any organic components that might be potential causes of infection or immune reaction.2

Increased Biocompatibility

The combination of porcine origin with the high level of purity enables predictable bone growth without risking an immunogenic reaction. In an In-Vitro study THE GraftTM was shown to encourage cell adhesion to the same extent as the compared DBBM (Deproteinized bovine bone matrix), and therefore offering optimal conditions for vital cell growth.

Increased Porosity

The high porosity of THE GraftTM means a quicker absorption of fluids (e.g; blood) in comparison with DBBM. This not only facilitates the application of the material but also leads to early remodelling and improved clinical performance.

​Increased Hydrophilicity

THE GraftTM has shown to have higher wettability than the compared xenografts.5 Wettability is important for the attachment, growth and profileration for various types of cells including osteoblasts.

THE Graft Biocompatibility

  • THE Graft™ is structurally similar to human bone
  • THE Graft™ is derived from deproteinized porcine cancellous bone
  • THE Graft™ has high levels of porosity and a natural interconnectivity
  • THE Graft™ has a very high level of purity without risking an immunogenic reaction
  • THE Graft™ provides the optimized bone architecture for cell adhesions and tissue regeneration

 

 

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References

1. Lee JS, Cha JK, Kim CS. Alveolar ridge regeneration of damaged extraction sockets using deproteinized porcine versus bovine bone minerals: a randomized clinical trial. Clin Implant Dent Relat Res. 2018;20(5):729-37.

2. Lee JH, Yi GS, Lee JW, Kim DJ. Physicochemical characterization of porcine bone-derived grafting material and comparison with bovine xenografts for dental applications. J Periodontal Implant Sci. 2017;47(6):388-401.

3. Figueiredo MJ, Fernando A, Martins G, Freitas J, Judas F, Figueiredo H. Effect of the calcination temperature on the composition and microstructure of hydroxyapatite derived from human and animal bone. Ceramics Int. 2010;36(8):2383-93.

4. Renders GA, Mulder L, van Ruijven LJ, van Eijden TM. Porosity of human mandibular condylar bone. J Anat. 2007;210(3):239-248.

5. Go A, Kim SE, Shim KM, Lee SM, Choi SH, Son JS, Kang SS. Osteogenic effect of low-temperature-heated porcine bone particles in a rat calvarial defect model. J Biomed Mater Res A. 2014;102(10):3609-17

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THE Graft™